By radically changing the delivery of insulin, Robert Langer, a professor at the Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, and his colleagues hope to make insulin treatment more palatable.
The research features in the journal Science.
Using microneedles to deliver the drug
The team came up with an innovative new design for a pill that consists of a biodegradable capsule containing an insulin microneedle. When a person swallows the pill, insulin injects directly into the stomach wall.
As the stomach lining does not have any pain receptors, the researchers believe that this way of delivering the drug will be free of pain.
“We are really hopeful that this new type of capsule could someday help diabetic patients and perhaps anyone who requires therapies that can now only be given by injection or infusion,” explains Langer.
Microneedles are millimeter-size needles that scientists originally developed to penetrate the skin without causing pain.
The microneedle in this study had two components: a tip comprising compressed insulin, which penetrates the stomach wall, and a biodegradable shaft, which holds the tip in place.