Home Alzheimers/Dementia Radiation Treatment May Alleviate Symptoms Of Severe Alzheimer’s Disease

Radiation Treatment May Alleviate Symptoms Of Severe Alzheimer’s Disease

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  Alzheimer’s disease (AD) is a progressive neurodegenerative disease that involves damage in the brain’s nerve cells, leading to memory loss and disruption of cognitive functioning. In the United States, AD is one of the leading causes of death in older populations, making up 60–80% of dementia cases.

There is no cure to prevent or treat AD, although there are therapies to relieve and slow the progression of some of its symptoms.

Key symptoms of AD include memory loss, confusion, and the loss of other cognitive abilities such as reasoning and decision-making. Health experts characterize late-stage, severe AD by an inability to communicate as well as impaired movement.

Case study of people with severe AD

A recent pilot study — conducted by scientists at the Baycrest and Sunnybrook Health Centres in Toronto, and Cuttler & Associates in Vaughan, Canada — showed that administering low doses of radiation, such as from a CT scan, may improve quality of life in severe AD patients.

The study appears in the Journal of Alzheimer’s Disease.

Dr. Sean Symons, a scientist at the Sunnybrook Research Institute and author of the study, provided additional comments for this article.

The team wanted to determine if they could observe similar results from a 2015 case study. According to this research, a patient with severe AD who received low doses of radiation displayed significant improvement in cognitive abilities, speech, and movement to the point where they were able to transfer out from a hospice into a care home.

Oxidative stress, which can cause DNA and cellular damage, can contribute to the development of Alzheimer’s disease and other neurodegenerative diseases.

The authors of the study hypothesized that low-dose ionizing radiation (LDIR) stimulates the mechanisms that offer protection from the damaging effects of oxidative stress, alleviating some of the symptoms of AD.

Four participants between the ages of 81 to 90 years, with severe AD, received a total of three low-dose radiation treatments through normal CT brain scans, 2 weeks apart. The first treatment consisted of two scans with a total of 80 milligrays (mGy) of radiation, while the latter two treatments were 40 mGy each.

The study analyzed both quantitative measures — measuring cognitive, behavioral, and functional abilities — and qualitative measures, meaning observations and reports of interactions with family members and caretakers, to determine improvements in quality of life.

Increased alertness, awareness, and recognition

The quantitative measures displayed minor differences, while the authors noted these measures were not sufficient to observe significant changes in severe AD patients.

However, the researchers saw the most significant changes through the qualitative measures. For three of the four participants, their family or caretakers reported increased alertness, awareness of surroundings, and recognition within a day after their first treatment.

One of the participants “was able to get into his wheelchair easily and put his feet on the foot-rests when asked to do so. At a concert, he sang to the rhythm and applauded appropriately.”

Another participant’s family member noted, “He was excited to see me — he spoke to me right away and gave me multiple kisses — real kisses like years ago. He was clapping his hands to the music. My mom agreed [it’d] been years since he has done this.”

One of the participants showed no changes or improvements in qualitative or quantitative measures. However, in all participants, there was no evidence to suggest worsened conditions or symptoms after radiation.

Risks of low vs. high-dose radiation

Experts know that high amounts of radiation — cited in the paper as a threshold of 3 grays — cause DNA damage and increase the risk of health issues such as cancer. However, low doses, such as background radiation present in routine CT scans, may in some cases have beneficial health effects.

“In patients of this age, all greater than 80 years old, the long-term effects of radiation (such as radiation-induced cancers) are negligible,” Dr. Symons told Medical News Today. “However, if [we propose] ongoing treatment or treatment in younger patients with AD, then an assessment of the cumulative higher radiation dose and its risks would have to be balanced with the benefits of the treatment.”

Further, the paper states that brain damage from oxidative stress is potentially a greater risk that experts need to address.

With age, the antioxidant-producing mechanisms in the body become weaker and unable to repair DNA damage properly. This is particularly an issue for people with dementia, who are often dealing with the burden of oxidative stress in older age.

While high-dose radiation would further damage these mechanisms, a low dose can stimulate them and produce more antioxidants to combat oxidative damage.

While the outcomes were overall positive for this case study, they have limitations due to the small sample size, as well as the lack of a control group or effective measures of oxidative stress. These results require further examination through larger follow-up clinical trials.

Additionally, the authors state that determining the optimal dose and the optimal time between doses will help increase the effectiveness and duration against AD symptoms.

According to the paper, “The primary goal of a therapy for old[er] adults with AD should be to improve the quality of their lives by optimizing their well-being, staying brain health[y], and restoring communication with family and friends to avoid social isolation, loneliness, and under-stimulation.”

MedicalNewsToday, posted on SouthFloridaReporter.comMay 8, 2021

Reprinted with permission

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